Neuregulin-3 - CISMeF

Preferred Label : Neuregulin-3;

NCIt synonyms : Neuregulin 3; NRG3; NRG-3; Neuregulin-3 Protein;

NCIt definition : Neuregulin-3 (359 aa, 38 kDa) is encoded by the human NRG3 gene. This protein is involved in signaling mediated by receptor tyrosine-protein kinase erbB-4.;

NCIt note : The active form of the growth factor, neuregulin-3, is produced when proteolytic cleavage removes 361 amino acids from the C-terminus of pro-neuregulin-3, membrane-bound isoform. The precursor is a type I membrane protein and the mature form is a secreted protein. (UniProt);

Details

Origin ID

C18180;

UMLS CUI

C0665692;

Automatic exact mappings (from CISMeF team)
- Neuregulin 3 [OMIM gene]
- neuregulin 3 [HGNC gene]
OMIM relation
- Neuregulin 3 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- NRG3 protein, human [MeSH Supplementary Concept]
- NRG3 protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Growth Factor Gene [NCIt concept]
- NRG3 Gene [NCIt concept]
gene_product_expressed_in_tissue
- Brain [NCIt concept]
- Testis [NCIt concept]
gene_product_has_associated_anatomy
- Extracellular Space [NCIt concept]
gene_product_has_biochemical_function
- Growth Factor [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- EGF-Like Domain [NCIt concept]
gene_product_is_element_in_pathway
- Agrin Pathway [NCIt concept]
- ERBB Family Signaling Pathway [NCIt concept]
- ERBB4 Signaling Pathway [NCIt concept]
- Epidermal Growth Factor Receptor Family Pathway [NCIt concept]
- Gamma-Secretase Mediated ErbB4 Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Differentiation Process [NCIt concept]
- Cell Growth [NCIt concept]
- Cell Proliferation [NCIt concept]
- Cell Proliferation Regulatory Process [NCIt concept]
- Intercellular Communication Process [NCIt concept]
- Receptor Binding [NCIt concept]
- Receptor Signaling [NCIt concept]

Keyword's position in hierarchy(ies) :

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