Integrin Alpha-5

Preferred Label : Integrin Alpha-5;

NCIt synonyms : FNRA; VLA5; ITGA5; Fibronectin Receptor Alpha Subunit; Integrin Alpha-F; VLA5A; Fibronectin Receptor Alpha Polypeptide; CD49e; Integrin Alpha 5; CD49 Antigen-Like Family Member E; CD49e Antigen; VLA-5;

NCIt definition : Integrin alpha-5 (1049 aa, 115 kDa) is encoded by the human ITGA5 gene. This protein plays a role in cell-matrix adhesion.;

NCIt note : Integrin alpha-5 is a type I membrane protein that contains 7 FG-GAP repeats and undergoes post-translational cleavage of the extracellular domain to yield disulfide-linked heavy and light chains that associate with integrin beta-1. Alpha-5/beta-1 acts as a fibronectin and fibrinogen receptor. Alpha-5 also may interact with HPS5.;

Details

Origin ID

C39592;

UMLS CUI

C1531430;

Automatic exact mappings (from CISMeF team)
- Integrin, alpha-5 [OMIM gene]
- integrin alpha5 [MeSH Descriptor]
- integrin alpha5 [MeSH concept]
- integrin alpha5beta1 [MeSH Descriptor]
OMIM relation
- Integrin, alpha-5 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
UMLS correspondences (same concept)
- ITGA5 protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- NCIt COVID-19 Clinical Terminology [NCIt concept]
- NCIt COVID-19 Terminology [NCIt concept]
gene_encodes_gene_product
- Cell Adhesion Molecule Gene [NCIt concept]
- ITGA5 Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
gene_product_affected_by_chemical_or_drug
- Intetumumab [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_chemical_classification
- Glycoprotein [NCIt concept]
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_biomarker_type
- Cluster of Differentiation [NCIt concept]
gene_product_is_element_in_pathway
- Actin Cytoskeleton Regulation Pathway [NCIt concept]
- Angiopoietin-1 Receptor Signaling Pathway [NCIt concept]
- Arrhythmogenic Right Ventricular Cardiomyopathy Pathway [NCIt concept]
- Bacterial Invasion of Epithelial Cell Pathway [NCIt concept]
- Dilated Cardiomyopathy Pathway [NCIt concept]
- ECM-Receptor Interaction Signaling Pathway [NCIt concept]
- Focal Adhesion Pathway [NCIt concept]
- Hematopoietic Cell Lineage Pathway [NCIt concept]
- Hypertrophic Cardiomyopathy Pathway [NCIt concept]
- Phagocytosis Pathway [NCIt concept]
- Shigellosis Pathway [NCIt concept]
- Syndecan-2-Mediated Signaling Pathway [NCIt concept]
- Syndecan-4-Mediated Signaling Pathway [NCIt concept]
- VEGFR3 Lymphatic Signaling Pathway [NCIt concept]
gene_product_is_physical_part_of
- Integrin [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Adhesion Process [NCIt concept]
- Heterodimerization [NCIt concept]
- Ligand Binding [NCIt concept]
- Receptor Signaling [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients