" /> Intetumumab - CISMeF





Preferred Label : Intetumumab;

NCIt synonyms : Immunoglobulin G1, anti-(human integrin alpha-V (vitronectin receptor subunit alpha or CD51)); Human Anti-Alpha-5 Integrin Monoclonal Antibody; Human Monoclonal CNTO 95 gamma1 heavy chain (222-215')-disulfide with Human Monoclonal CNTO 95 kappa light chain dimer (228-228'':231-231'')-bisdisulfide;

NCIt definition : A pan alpha-v human monoclonal antibody that recognizes alpha-v beta-1, alpha-v beta-3, alpha-v beta-5, and alpha-v beta-6 integrins with antiangiogenic and antitumor activities. Intetumumab competitively binds to and blocks both alpha-v beta-3 and alpha-v beta-5 integrins, resulting in inhibition of integrin-mediated tumor angiogenesis and tumor growth. Integrins facilitate the adhesion of stimulated endothelial cells to the extracellular matrix (ECM); trigger the secretion of ECM-rearranging proteases; and propagate signaling events that promote the survival and differentiation of cells in newly formed vasculature.;

UNII : GQE1BJE2NI;

CAS number : 725735-28-4; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 725735-28-4 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : CNTO 095; CNTO-95;

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15/05/2024


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