Preferred Label : Integrin AlphaV/Beta3;
NCIt synonyms : Integrin Alpha-V/Beta-3; aVBeta3 Integrin; aVBeta3; Integrin-aVBeta3; Integrin aVBeta3; aV/b3; Integrin aV/b3;
NCIt definition : Involved in cell adhesion and signaling, human Integrin-aVBeta3 is composed of type
I membrane protein chains Integrin Alpha V (disulfide-linked heavy and light chains)
and Integrin Beta 3 that recognize RGD sequences. Multiple heterodimeric alpha/beta
combinations result in different integrins. aV/beta-3 is a receptor for cytotactin,
fibronectin, laminin, MMP-2, osteopontin, osteomodulin, prothrombin, thrombospondin,
vitronectin, and von Willebrand factor. (NCI);
Origin ID : C38953;
UMLS CUI : C5441899;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- gene_product_affected_by_chemical_or_drug
- gene_product_has_associated_anatomy
- gene_product_has_biochemical_function
- gene_product_has_chemical_classification
- gene_product_plays_role_in_biological_process
- has_gene_product_element
- is_target
- related_to_genetic_biomarker
