Preferred Label : integrin alphavbeta3;
MeSH definition : An integrin that binds to a variety of plasma and extracellular matrix proteins containing
the conserved RGD amino acid sequence and modulates cell adhesion. Integrin alphavbeta3
is highly expressed in OSTEOCLASTS where it may play role in BONE RESORPTION. It is
also abundant in vascular smooth muscle and endothelial cells, and in some tumor cells,
where it is involved in angiogenesis and cell migration. Although often referred to
as the vitronectin receptor there is more than one receptor for vitronectin (RECEPTORS,
VITRONECTIN).;
MeSH synonym : alpha v beta 3 integrin receptors; beta-3, integrin alpha-v; integrin alpha-v beta-3; receptors, alpha v beta 3 integrin; alphavbeta3, integrin; integrin alpha v beta 3; alpha-v beta-3, integrin; alpha-v beta-3 integrin receptors; receptors, alpha-v beta-3 integrin; vitronectin receptor; receptor, vitronectin;
MeSH annotation : do not confuse X ref VITRONECTIN RECEPTOR with VITRONECTIN RECEPTORS; do not confuse entry term VITRONECTIN RECEPTOR with VITRONECTIN RECEPTORS;
Is substance : O;
Origin ID : D039302;
UMLS CUI : C1138427;
Allowable qualifiers
- Indexing information
- CP-4715 [MeSH Supplementary Concept]
- IH1062 [MeSH Supplementary Concept]
- SH 066 [MeSH Supplementary Concept]
- TA 138 [MeSH Supplementary Concept]
- Record concept(s)
- See also
- Semantic type(s)
- UMLS correspondences (same concept)
An integrin that binds to a variety of plasma and extracellular matrix proteins containing
the conserved RGD amino acid sequence and modulates cell adhesion. Integrin alphavbeta3
is highly expressed in OSTEOCLASTS where it may play role in BONE RESORPTION. It is
also abundant in vascular smooth muscle and endothelial cells, and in some tumor cells,
where it is involved in angiogenesis and cell migration. Although often referred to
as the vitronectin receptor there is more than one receptor for vitronectin (RECEPTORS,
VITRONECTIN).
