Integrin Receptor Antagonist GLPG0187

Preferred Label : Integrin Receptor Antagonist GLPG0187;

NCIt related terms : GLPG-0187;

NCIt definition : A small molecule integrin receptor antagonist (IRA) with potential antineoplastic activity. Upon administration, GLPG0187 binds to and blocks the activity of 5 RGD-integrin receptor subtypes, including alphavbeta1, alphavbeta3, alphavbeta5, alphavbeta6 and alpha5beta1. This may result in the inhibition of endothelial cell-cell interactions and endothelial cell-matrix interactions, and the prevention of angiogenesis and metastasis in tumor cells expressing these integrin receptors. Integrin receptors are transmembrane glycoproteins expressed on the surface of tumor vessel endothelial cells and some types of cancer cells, and play a crucial role in endothelial cell adhesion and migration.;

UNII : 43A5P87Z4T;

CAS number : 1320346-97-1;

Molecule name : GLPG0187;

NCI Metathesaurus CUI : CL429007;

Details

Origin ID

C96223;

UMLS CUI

C3272654;

Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- GLPG0187 [MeSH Supplementary Concept]
chemical_or_drug_has_mechanism_of_action
- Integrin Inhibition [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Cell Adhesion Inhibition [NCIt concept]
- Negative Regulation of Angiogenesis [NCIt concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Integrin AlphaV/Beta3 [NCIt concept]
- Integrin AlphaV/Beta5 [NCIt concept]

Keyword's position in hierarchy(ies) :

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