" /> Integrin Receptor Antagonist GLPG0187 - CISMeF





Preferred Label : Integrin Receptor Antagonist GLPG0187;

NCIt related terms : GLPG-0187;

NCIt definition : A small molecule integrin receptor antagonist (IRA) with potential antineoplastic activity. Upon administration, GLPG0187 binds to and blocks the activity of 5 RGD-integrin receptor subtypes, including alphavbeta1, alphavbeta3, alphavbeta5, alphavbeta6 and alpha5beta1. This may result in the inhibition of endothelial cell-cell interactions and endothelial cell-matrix interactions, and the prevention of angiogenesis and metastasis in tumor cells expressing these integrin receptors. Integrin receptors are transmembrane glycoproteins expressed on the surface of tumor vessel endothelial cells and some types of cancer cells, and play a crucial role in endothelial cell adhesion and migration.;

UNII : 43A5P87Z4T;

CAS number : 1320346-97-1;

Molecule name : GLPG0187;

NCI Metathesaurus CUI : CL429007;

Détails


Vous pouvez consulter :


Nous contacter.
31/07/2025


[Accueil] [Haut de page]

© CHU de Rouen. Toute utilisation partielle ou totale de ce document doit mentionner la source.