Preferred Label : Thyrointegrin AlphaVBeta3 Antagonist fb-PMT;
NCIt synonyms : Fluorobenzyl Polyethylene Glycol Conjugated Tetraiodothyroacetic Acid; AlphaV/Beta3 Antagonist fb-PMT; fb-PMT;
NCIt definition : A fluorobenzyl polyethylene glycol (PEG) conjugated to tetraiodothyroacetic acid that
targets the thyrointegrin alphaVbeta3, with potential antineoplastic activity. Upon
administration, the thyrointegrin alphaVbeta3 antagonist fb-PMT targets and binds
to alphaVbeta3 integrin. This results in the inhibition of angiogenesis and metastasis.
The mechanism of actions (MOAs) through which fb-PMT exerts its actions may be more
complex and may be through multiple signaling pathways. AlphaVbeta3 integrin, a cell
adhesion and signaling receptor, is overexpressed on the surface of tumor vessel endothelial
cells, some tumor cells, and a number of other cell types.;
Molecule name : NP-751; NP 100; NP 751; NP-100;
NCI Metathesaurus CUI : CL1799321;
Origin ID : C190790;
UMLS CUI : C5777098;
Semantic type(s)
- concept_is_in_subset
- has_target
