NCIt related terms : humanized monoclonal antibody MEDI-522; MEDI-522; Abegrin;
NCIt definition : A humanized monoclonal IgG1 antibody directed against the vitronectin receptor alpha
v beta 3 integrin. Etaracizumab blocks the binding of ligands, such as vitronectin,
to alpha v beta 3 integrin, resulting in inhibition of angiogenesis and metastasis.
Alpha v beta 3 integrin is a cell adhesion and signaling receptor that is expressed
on the surface of tumor vessel endothelial cells, some tumor cells, and a number of
other cell types.;
Alternative definition : NCI-GLOSS: A substance being studied in the treatment of some types of cancer and
other conditions. Abegrin binds to a protein on the surface of blood vessels and may
prevent the growth of new blood vessels that tumors need to grow. It may also prevent
the spread of cancer. It is a type of antiangiogenesis agent, a type of metastasis
inhibitor, and a type of monoclonal antibody.;
UNII : 41W9MFI160;
CAS number : 892553-42-3; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 892553-42-3
alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo
G-SRS /a ;
Drug name : Abegrin;
Molecule name : MEDI-522;
NSC code : 719850;
Codes from synonyms : CDR0000641719; CDR0000633068; CDR0000633069; CDR0000633070;