Vitaxin-2 - CISMeF

Preferred Label : Vitaxin-2;

NCIt synonyms : Monoclonal Antibody Anti-Avb3 Integrin; Vitaxin 2;

NCIt definition : A modified version of Vitaxin, a humanized monoclonal IgG1 antibody to alpha(v)beta(3)integrin. Exhibiting improved affinity to alpha(v)beta(3)integrin compared to first-generation Vitaxin, Vitaxin-2 blocks the binding of ligands, such as vitronectin, to alpha(v)beta(3) integrin, thereby inhibiting endothelial cell-cell interactions, endothelial cell-matrix interactions, and angiogenesis. (NCI04);

Details

Origin ID

C2734;

UMLS CUI

C1523981;

Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
chemical_or_drug_affects_gene_product
- Integrin AlphaV/Beta3 [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Antigen Binding [NCIt concept]
is_component_of_chemotherapy_regimen
- Dacarbazine/Monoclonal Antibody Anti-Avb3 Integrin [NCIt concept]
- Docetaxel/Estramustine/Vitaxin-2/Zoledronate [NCIt concept]
- Docetaxel/Vitaxin-2 [NCIt concept]

Keyword's position in hierarchy(ies) :

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