Preferred Label : Lutetium Lu 177 FF58;
NCIt synonyms : [177Lu]-FF58; 177Lu-FF58;
NCIt definition : A radioconjugate composed of FF58, a non-arginine-glycine-aspartic acid (Arg-Gly-Asp/RGD)
small molecule targeting the transmembrane receptors integrin alpha V beta 3 (avb3)
and 5 (avb5), linked to the beta-emitting radioisotope lutetium Lu 177 (177Lu), with
potential antineoplastic activity against integrin avb3/5-expressing tumor cells.
Upon administration, lutetium Lu 177 FF58 targets and binds to integrin avb3/5-expressing
tumor cells. Upon binding, integrin avb3/5-expressing tumor cells are destroyed by
177Lu through the specific delivery of beta particle radiation. Integrin avb3/5, members
of the integrin receptor family, are overexpressed on certain tumor cells and tumor
endothelial cells while minimally or not expressed on healthy, normal cells; they
play key roles in angiogenesis, tumor proliferation and survival.;
NCI Metathesaurus CUI : CL1927308;
Origin ID : C205213;
concept_is_in_subset
- has_target
