Preferred Label : Fluorescent cRGDY PEG-Cy5.5 C Dots;
NCIt synonyms : cRGDY-PEG-Cy5.5-C Dots;
NCIt definition : An imaging agent composed of silica-based nanoparticles labeled with a near-infrared
(NIR) fluorophore, Cyanine 5.5 (Cy5.5) and surrounded by polyethylene glycol (PEG)
chains attached to cyclo-[Arg-Gly-Asp-Tyr] (cRGDY) peptides, with potential use as
a tumor-selective fluorescent imaging agent. Upon intradermal administration of the
fluorescent cRGDY PEG-Cy5.5 C dots, the cRGD moiety selectively binds to alphaVbeta3
integrin expressed on tumor cells. Upon intraoperative fluorescence imaging, alphaVbeta3-expressing
tumor cells can be visualized and the degree of both tumor metastasis and sentinel
lymph node (SLN) trafficking can be assessed. Integrins are transmembrane glycoproteins
upregulated on proliferating tumor vessel endothelial cells and various cancer cells;
their overexpression has been associated with neovascularization, differentiation,
proliferation of tumor cells, metastasis and an overall poor prognosis.;
NCI Metathesaurus CUI : CL472635;
Origin ID : C115104;
UMLS CUI : C3899111;
Semantic type(s)
- concept_is_in_subset
- has_target
