NCIt definition : A radiotracer containing a pegylated dimeric Arg-Gly-Asp (RGD) peptide (NH2-mini-PEG-E[c(RGDyK)]2
or PRGD2) radiolabeled with fluorine 18F-fluorobenzoate (18F-FB), with potential alphaVbeta3
integrin imaging activity upon positron emission topography (PET). Upon administration,
the RGD moiety of 18F-labeled Mini-PEG Spacered RGD Dimer (18F-FPRGD2) binds to alphaVbeta3
integrin. Upon PET, alphaVbeta3-expressing tumor cells can be visualized and the degree
of tumor angiogenesis can be determined. This agent exhibits increased integrin receptor
binding affinity, tumor cell uptake and increased radiolabeling yield as compared
to the non-pegylated form (18F-FRGD2). Integrins, transmembrane glycoproteins, may
be upregulated on proliferating tumor vessel endothelial cells and various cancer
cells; their overexpression has been associated with neovascularization, differentiation,
proliferation of tumor cells, metastasis and an overall poor prognosis.;
Automatic exact mappings (from CISMeF team)