Cilengitide - CISMeF

Preferred Label : Cilengitide;

NCIt synonyms : cyclo(L-arginylglycyl-L-a-aspartyl-D-phenylalanyl-N-methyl-L-valyl);

NCIt related terms : EMD 121974; EMD-121974;

NCIt definition : A cyclic Arg-Gly-Asp peptide with potential antineoplastic activity. Cilengitide binds to and inhibits the activities of the alpha(v)beta(3) and alpha(v)beta(5) integrins, thereby inhibiting endothelial cell-cell interactions, endothelial cell-matrix interactions, and angiogenesis. (NCI04);

Alternative definition : NCI-GLOSS: A substance that is being studied as an anticancer and antiangiogenesis drug.;

UNII : 4EDF46E4GI;

InChIKey : AMLYAMJWYAIXIA-VWNVYAMZSA-N;

CAS number : 188968-51-6;

Molecule name : EMD 121974;

Chemical formula : C27H40N8O7;

NSC code : 707544;

Codes from synonyms : CDR0000315757; 31655; CDR0000044887; NSC0707544;

Details

Origin ID

C1834;

UMLS CUI

C0971473;

Currated CISMeF NLP mapping
- Cilengitide [MeSH concept]
- Cilengitide [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Cilengitide [MeSH concept]
- Cilengitide [MeSH Supplementary Concept]
chemical_or_drug_affects_cell_type_or_tissue
- Vascular Endothelium [NCIt concept]
chemical_or_drug_affects_gene_product
- Integrin AlphaV/Beta3 [NCIt concept]
- Integrin AlphaV/Beta5 [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Integrin Inhibition [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Cell Adhesion Inhibition [NCIt concept]
- Negative Regulation of Angiogenesis [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Integrin AlphaV/Beta3 [NCIt concept]
- Integrin AlphaV/Beta5 [NCIt concept]

Keyword's position in hierarchy(ies) :

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