Preferred Label : Integrin Beta-3;
NCIt synonyms : Platelet Membrane Glycoprotein IIIa; ITGB3; CD61; GPIIIa; Integrin Beta Chain Beta 3; Platelet Glycoprotein IIIa; Antigen CD61; GP3A; CD61 Antigen; GP IIIa;
NCIt definition : Integrin beta-3 (788 aa, 87 kDa) is encoded by the human ITGB3 gene. This protein
plays a role in cell-matrix adhesion, integrin signaling and pathological angiogenesis.;
NCIt note : Type I membrane protein Integrin Beta 3 contains a VWFA-like domain and is involved
in cell adhesion and signaling. ITGB3 associates with alphaIIB or alphaV and recognize
RGD; aIIB/beta-3 also recognizes HHLGGGAKQAGDV in FN gamma. Beta-3C interacts with
FLNB. aV/beta-3 is a receptor for cytotactin, fibronectin, laminin, MMP-2, osteopontin,
osteomodulin, prothrombin, thrombospondin, vitronectin, and von Willebrand factor.
Receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin, and
vitronectin, aIIB/beta-3 binds fibrinogen to induce platelet aggregation and plug
ruptured endothelia. In response to platelet aggregation, Tyr-773/785 phosphorylated
ITGB3 appears to bind GRB2/SHC. ITGB3 defects cause Glanzmann thrombasthenia (GT).;
Origin ID : C38955;
UMLS CUI : C0638262;
Currated CISMeF NLP mapping
- OMIM relation
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- gene_encodes_gene_product
- gene_product_affected_by_chemical_or_drug
- gene_product_has_associated_anatomy
- gene_product_has_biochemical_function
- gene_product_has_chemical_classification
- gene_product_has_structural_domain_or_motif
- gene_product_is_biomarker_type
- gene_product_is_element_in_pathway
- gene_product_is_physical_part_of
- gene_product_plays_role_in_biological_process
