Integrin Alpha-IIb/Beta-3

Preferred Label : Integrin Alpha-IIb/Beta-3;

NCIt synonyms : Integrin Alpha-2b/Beta-3; Alpha2b/Beta3; Glycoprotein IIb/IIIa; gpIIb/IIIa; Alpha 2b/Beta 3 Integrin; Alpha-IIb/Beta-3; Alpha 2b/Beta 3; GP IIb/IIIa; Alpha-IIb/Beta-3 Integrin; Alpha2b/Beta3 Integrin; Integrin Alpha-IIb Beta-3;

NCIt definition : Integrin alpha-IIb/beta3 is a protein complex comprised of a heterodimer of integrin alpha 2b and integrin beta 3. This complex is involved in cell adhesion and blood clot formation.;

NCIt note : Integrin Alpha-IIb/Beta3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the amino acid sequence R-G-D in a wide array of ligands and H-H-L-G-G-G-A-K-Q-A-G-D-V in the fibrinogen gamma chain. Following activation, integrin alpha-IIb/beta-3 binds to soluble fibrinogen and catalyzes rapid platelet aggregation. (UniProt);

Details

Origin ID

C77161;

UMLS CUI

C0016011;

Biochemical function of gene products
- Integrin Alpha-IIb [NCIt concept]
Currated CISMeF NLP mapping
- platelet glycoprotein GPIIb-IIIa complex [MeSH concept]
- platelet glycoprotein GPIIb-IIIa complex [MeSH Descriptor]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Receptor [UMLS semantic type]
UMLS correspondences (same concept)
- platelet glycoprotein GPIIb-IIIa complex [MeSH concept]
- platelet glycoprotein GPIIb-IIIa complex [MeSH Descriptor]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Cell Adhesion Molecule [NCIt concept]
gene_product_has_chemical_classification
- Glycoprotein [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Adhesion Process [NCIt concept]
- Leukocyte Trafficking [NCIt concept]
- Ligand Binding [NCIt concept]
- Platelet Aggregation Process [NCIt concept]
- Protein-Protein Interaction [NCIt concept]
- Receptor Signaling [NCIt concept]
- Wound Repair [NCIt concept]
has_gene_product_element
- Integrin Beta-3 [NCIt concept]
related_to_genetic_biomarker
- ITGA2B Gene [NCIt concept]
- ITGB3 Gene [NCIt concept]

Keyword's position in hierarchy(ies) :

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