" /> Integrin Alpha-IIb/Beta-3 - CISMeF





Preferred Label : Integrin Alpha-IIb/Beta-3;

NCIt synonyms : Integrin Alpha-2b/Beta-3; Alpha2b/Beta3; Glycoprotein IIb/IIIa; gpIIb/IIIa; Alpha 2b/Beta 3 Integrin; Alpha-IIb/Beta-3; Alpha 2b/Beta 3; GP IIb/IIIa; Alpha-IIb/Beta-3 Integrin; Alpha2b/Beta3 Integrin; Integrin Alpha-IIb Beta-3;

NCIt related terms : CD41/61; Platelet GPIIb/IIIa; Integrin Alpha IIb/Beta 3; PLATELET GLYCOPROTEIN IIB/IIIA;

NCIt definition : Integrin alpha-IIb/beta3 is a protein complex comprised of a heterodimer of integrin alpha 2b and integrin beta 3. This complex is involved in cell adhesion and blood clot formation.;

Alternative definition : CDISC: A glycoprotein complex and platelet surface receptor composed of the transmembrane GPIIb and GPIIIa subunits. It mediates platelet adhesion, activation, clearance, and thrombopoiesis. This complex can be considered as an autoantigen and is commonly associated with autoimmune thrombocytopenic purpura.;

NCIt note : Integrin Alpha-IIb/Beta3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the amino acid sequence R-G-D in a wide array of ligands and H-H-L-G-G-G-A-K-Q-A-G-D-V in the fibrinogen gamma chain. Following activation, integrin alpha-IIb/beta-3 binds to soluble fibrinogen and catalyzes rapid platelet aggregation. (UniProt);

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23/05/2025


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