platelet glycoprotein GPIIb-IIIa complex

Preferred Label : platelet glycoprotein GPIIb-IIIa complex;

MeSH definition : Platelet membrane glycoprotein complex important for platelet adhesion and aggregation. It is an integrin complex containing INTEGRIN ALPHAIIB and INTEGRIN BETA3 which recognizes the arginine-glycine-aspartic acid (RGD) sequence present on several adhesive proteins. As such, it is a receptor for FIBRINOGEN; VON WILLEBRAND FACTOR; FIBRONECTIN; VITRONECTIN; and THROMBOSPONDINS. A deficiency of GPIIb-IIIa results in GLANZMANN THROMBASTHENIA.;

MeSH synonym : integrin alphaiibbeta3; gpiib iiia receptors; alphaiibbeta3, integrin; glycoproteins iib iiia; integrin alpha iib beta 3; gpiib-iiia receptors; receptors, gpiib-iiia; glycoproteins iib-iiia; integrin alpha-iib beta-3; beta-3, integrin alpha-iib; platelet glycoprotein GPIIb IIIa complex;

Wikipedia link : https://en.wikipedia.org/wiki/Platelet glycoprotein gpiib-iiia complex;

Is substance : O;

Details

Origin ID

D019039;

UMLS CUI

C0016011;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- agonists [MeSH Qualifier]
- analogs and derivatives [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Currated CISMeF NLP mapping
- Integrin Alpha-IIb/Beta-3 [NCIt concept]
Indexing information
- 2-(N-(3-pyridylsulfonyl)amino)-3-((2-carbonyl-5-(2-(piperidin-4-yl)ethyl)thieno(2,3-b)thiopheneyl)amino)propionic acid [MeSH Supplementary Concept]
- 2-benzenesulfonylamino-3-(4-(2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl)benzoylamino)propionic acid [MeSH Supplementary Concept]
- 3-((2-(4-(N-hydroxycarbamimidoyl)phenyl)-1-oxo-2,8-diazaspiro(4,5)decane-8-carbonyl)amino)propionic acid ethyl ester [MeSH Supplementary Concept]
- 3-(4-(aminoiminomethyl)phenyl)-5-((((2-carboxy-2-((3-methylphenyl)sulfonamido)ethyl)amino)carbonyl)methyl)-2-methylisoxazole [MeSH Supplementary Concept]
- 6-((4-amidinobenzoyl)amino)tetralone-2-acetic acid [MeSH Supplementary Concept]
- Abciximab [MeSH Descriptor]
- CP-4715 [MeSH Supplementary Concept]
- CRL 42796 [MeSH Supplementary Concept]
- DMP 444 [MeSH Supplementary Concept]
- DMP 755 [MeSH Supplementary Concept]
- DMP 802 [MeSH Supplementary Concept]
- EP 224283 [MeSH Supplementary Concept]
- Eptifibatide [MeSH Descriptor]
- L 742998 [MeSH Supplementary Concept]
- L 767679 [MeSH Supplementary Concept]
- ME 3277 [MeSH Supplementary Concept]
- MS 180 [MeSH Supplementary Concept]
- RGD891 [MeSH Supplementary Concept]
- SDZ GPI 562 [MeSH Supplementary Concept]
- SM 20302 [MeSH Supplementary Concept]
- SR 121566 [MeSH Supplementary Concept]
- TAK 024 [MeSH Supplementary Concept]
- TAK 029 [MeSH Supplementary Concept]
- TS 943 [MeSH Supplementary Concept]
- Tirofiban [MeSH Descriptor]
- XR 300 [MeSH Supplementary Concept]
- XU 063 [MeSH Supplementary Concept]
- XV 459 [MeSH Supplementary Concept]
- batifiban [MeSH Supplementary Concept]
- ethyl 3-(2-(4-(4-aminoiminomethylphenyl)-4-methyl-2,5-dioxoimidazolidin-1-yl)acetylamino)-3-phenylpropionate [MeSH Supplementary Concept]
- ethyl N-(3-(2-fluoro-4-(thiazolidin-3-yl(imino)methyl)benzoyl)amino-2,2-dimethylpentanoyl)piperidine-4-acetate [MeSH Supplementary Concept]
- fradafiban [MeSH Supplementary Concept]
- klerval [MeSH Supplementary Concept]
- lefradafiban [MeSH Supplementary Concept]
- lotrafiban [MeSH Supplementary Concept]
- orotyl-seryl-arginyl-glycyl-aspartyl-tryptophane [MeSH Supplementary Concept]
- ro 44-3888 [MeSH Supplementary Concept]
- ro 48-3656 [MeSH Supplementary Concept]
- roxifiban [MeSH Supplementary Concept]
- sibrafiban [MeSH Supplementary Concept]
- tablysin-15, tabanus yao [MeSH Supplementary Concept]
Record concept(s)
- platelet glycoprotein GPIIb-IIIa complex [MeSH concept]
Related MeSH Supplementary Concept(s)
- platelet glycoprotein (GP)IIIa 49-66 [MeSH Supplementary Concept]
Related MeSH term(s)
- thrombasthenia [MeSH Descriptor]
See also
- integrin beta3 [MeSH Descriptor]
- platelet membrane glycoprotein IIb [MeSH Descriptor]
- thrombasthenia [MeSH Descriptor]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Receptor [UMLS semantic type]
UMLS correspondences (same concept)
- Integrin Alpha-IIb/Beta-3 [NCIt concept]

Keyword's position in hierarchy(ies) :

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