" /> Integrin, beta-3 - CISMeF





Preferred Label : Integrin, beta-3;

Symbol : ITGB3;

CISMeF acronym : CD61; GP3A; ITGB3;

Type : Gene;

Alternative titles and symbols : Platelet glycoprotein iiia; Gp iiia; Platelet fibrinogen receptor, beta subunit; GP3A; CD61;

Description : The ITGB3 gene encodes glycoprotein IIIa (GP IIIa), the beta subunit of the platelet membrane adhesive protein receptor complex GP IIb/IIIa. The alpha subunit, GP IIb, is encoded by the ITGA2B gene (607759). The GP IIb/IIIa complex belongs to the integrin class of cell adhesion molecule receptors that share a common heterodimeric structure with alpha and beta subunits. Glycoprotein IIIa is also the beta subunit of 2 other integrins, fibronectin receptor (FNRB; 135630) and vitronectin receptor (193210), which have distinctive alpha subunits.;

Inheritance : Autosomal recessive;

Molecular basis : Caused by mutations in the platelet glycoprotein IIIa gene (ITGB3, 173470.0001);

Laboratory abnormalities : Platelet glycoprotein IIIa deficiency; Decreased clot retraction; Normal platelet count; Platelet aggregation defect;

Ensembl ID : ENSG00000259207;

Prefixed ID : *173470;

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15/05/2024


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