Preferred Label : Internalized-arginylglycylaspartic Acid Cyclic Peptide;
NCIt synonyms : iRGD; L-Cysteine, L-Cysteinyl-L-Arginylglycyl-L-.Alpha.-Aspartyl-L-Lysylglycyl-L-Prolyl-L-.Alpha.-Aspartyl-,
Cyclic (1- 9)-Disulfide;
NCIt definition : A 9 amino acid-based cyclic, tumor specific homing, arginine-glycine-aspartic acid
(RGD)-based peptide (CRGDKRGPDC), with tumor penetrating activity. The iRGD contains
the RGD motif as well as the C-terminal end binding (CendR) motif that increases internalization.
Upon administration, the RGD motif of the iRGD peptide is able to specifically target
tumors by binding to alphavbeta3/alphavbeta5 integrins on tumor endothelium. In turn,
iRGD is cleaved by specific tumor proteases, which exposes the positively charged
CendR motif. This motif binds to neuropilin-1 (NRP-1), a receptor overexpressed on
certain tumor cells. This increases vascular permeability of tumor blood vessels and
promotes tumor penetration. Compared to other RGD peptides, this agent is able to
both improve delivery and increase the accumulation of co-administered or conjugated
chemotherapeutic agents in the tumor.;
UNII : Z8MXU5GH4Q;
CAS number : 1392278-76-0;
Molecule name : CEND 1; CEND-1; LSTA 1; LSTA-1;
NCI Metathesaurus CUI : CL438336;
Origin ID : C103858;
UMLS CUI : C3641657;
Semantic type(s)
- concept_is_in_subset
- has_target
