Integrin Alpha-V

Preferred Label : Integrin Alpha-V;

NCIt synonyms : ITGAV Protein; Vitronectin Receptor Alpha Subunit CD51 Antigen; CD51 Antigen; Vitronectin Receptor Subunit Alpha; Integrin Alpha V;

NCIt definition : Integrin alpha-V (1148 aa, 116 kDa) is encoded by the human ITGAV gene. This protein plays a role in cell-matrix adhesion and pathological angiogenesis.;

NCIt note : Human integrin alpha-V protein is a type I membrane protein that forms a heterodimer with an integrin beta protein (either the beta-1, 3, 5, 6 or 8 polypeptide). The resulting complex binds to the tripeptide R-G-D, an amino acid sequence present in a number of ligands including vitronectin, fibronectin, fibrinogen, and laminin. Ligand binding regulates cell adhesion, growth and migration.;

Details

Origin ID

C53961;

UMLS CUI

C4082291;

Automatic exact mappings (from CISMeF team)
- Integrin, alpha-V [OMIM gene]
- integrin alphaV [MeSH concept]
- integrin alphav [MeSH Descriptor]
OMIM relation
- Integrin, alpha-V [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Cell Adhesion Molecule Gene [NCIt concept]
- ITGAV Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_biomarker_type
- Cluster of Differentiation [NCIt concept]
gene_product_is_element_in_pathway
- Actin Cytoskeleton Regulation Pathway [NCIt concept]
- Arrhythmogenic Right Ventricular Cardiomyopathy Pathway [NCIt concept]
- Cell Adhesion Molecule Signaling Pathway [NCIt concept]
- Dilated Cardiomyopathy Pathway [NCIt concept]
- Focal Adhesion Pathway [NCIt concept]
- Hypertrophic Cardiomyopathy Pathway [NCIt concept]
- Nectin Adhesion Pathway [NCIt concept]
- Osteopontin-Mediated Signaling Pathway [NCIt concept]
- PDGFR-alpha Signaling Pathway [NCIt concept]
- PDGFR-beta Signaling Pathway [NCIt concept]
- Phagocytosis Pathway [NCIt concept]
- Phospholipid Signaling Pathway [NCIt concept]
- Small Cell Lung Cancer Pathway [NCIt concept]
- Sphingosine 1-Phosphate Receptor 1 Signaling Pathway [NCIt concept]
- Sphingosine 1-Phosphate Receptor 3 Signaling Pathway [NCIt concept]
gene_product_is_physical_part_of
- Integrin AlphaV/Beta1 [NCIt concept]
- Integrin AlphaV/Beta3 [NCIt concept]
- Integrin AlphaV/Beta5 [NCIt concept]
- Integrin AlphaV/Beta6 [NCIt concept]
- Integrin AlphaV/Beta8 [NCIt concept]
gene_product_plays_role_in_biological_process
- Angiogenic Process [NCIt concept]
- Cell Adhesion Process [NCIt concept]
- Heterodimerization [NCIt concept]
- Ligand Binding [NCIt concept]
- Receptor Signaling [NCIt concept]

Keyword's position in hierarchy(ies) :

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