" /> Abituzumab - CISMeF





Preferred Label : Abituzumab;

NCIt synonyms : Anti-alphaVbeta3 Monoclonal Antibody EMD 525797;

NCIt definition : A humanized monoclonal antibody directed against the human alpha v integrin subunit with potential antiangiogenic and antineoplastic activities. Abituzumab, a chimeric antibody which includes the antigen binding sites of the anti-integrin mouse antibody 17E6, binds to and inhibits the activity of alphaVbeta3 integrin (vitronectin receptor); this may result in the inhibition of endothelial cell-cell interactions, endothelial cell-matrix interactions, and integrin-mediated tumor angiogenesis and metastasis in alphavbeta3-expressing tumor cells. AlphaVbeta3 integrin, a cell adhesion and signaling receptor, is expressed on the surface of tumor vessel endothelial cells and plays a crucial role in endothelial cell adhesion and migration.;

UNII : 724QD330RD;

CAS number : 1105038-73-0; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1105038-73-0 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : EMD 525797;

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15/05/2024


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