" /> Leukocyte Surface Antigen CD47 - CISMeF





Preferred Label : Leukocyte Surface Antigen CD47;

NCIt synonyms : OA3; Antigenic Surface Determinant Protein OA3; CD47 Glycoprotein; IAP; CD47 Antigen; Integrin Associated Protein; CD47 Antigen (Rh-Related Antigen, Integrin-Associated Signal Transducer); CD47; MER6; Surface Antigen Identified by Monoclonal Antibody 1D8; Integrin-Associated Protein; Rh-Related Antigen; Integrin-Associated Signal Transducer; Protein MER6;

NCIt definition : Leukocyte surface antigen CD47 (323 aa, 35 kDa) is encoded by the human CD47 gene. This protein plays a role in both cell adhesion and T-cell activation.;

NCIt note : CD47 Antigen, encoded by the CD47 gene, is a 50-kD membrane protein with an amino-terminal immunoglobulin domain and a carboxyl-terminal multiple-membrane-spanning region. CD47 Antigen is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. It is also involved in membrane permeability changes induced following virus infection. Interactions of thrombospondins with alpha4beta1 integrin and CD47 differentially modulate T cell behavior. The interaction of CD47 with SHPS-1 may contribute to the recruitment of B lymphocytes via endothelial cells under steady state conditions. CD47 Antigen is very broadly distributed on normal adult tissues, as well as ovarian tumors, being especially abundant in some epithelia and the brain. Four isoforms are produced by alternative splicing. (From LocusLink, OMIM, Swiss-Prot and NCI);

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12/05/2024


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