Preferred Label : Anti-CD47 Monoclonal Antibody MIL95;
NCIt definition : A humanized monoclonal antibody targeting leukocyte surface antigen CD47, with potential
immune checkpoint inhibitory and antineoplastic activities. Upon administration, anti-CD47
monoclonal antibody MIL95 targets and binds to CD47 expressed on tumor cells, blocking
the interaction of CD47 with signal regulatory protein alpha (SIRPa) expressed on
phagocytic cells. This prevents CD47/SIRPa-mediated signaling and abrogates the CD47/SIRPa-mediated
inhibition of macrophage activation and phagocytosis of cancer cells. This induces
pro-phagocytic signaling mediated by the binding of calreticulin (CRT), which is specifically
expressed on the surface of tumor cells, to low-density lipoprotein (LDL) receptor-related
protein-1 (LRP-1), which is expressed on macrophages, and results in macrophage activation
and the specific phagocytosis of tumor cells. CD47, also called integrin-associated
protein (IAP), is a tumor-associated antigen (TAA) expressed on normal, healthy hematopoietic
stem cells (HSCs) and overexpressed on the surface of a variety of cancer cells. Expression
of CD47, and its interaction with SIRPa, leads to the inhibition of macrophage activation
and protects cancer cells from phagocytosis, thereby allowing cancer cells to proliferate.;
Molecule name : CM 312; CM-312; MIL-95; MIL 95;
NCI Metathesaurus CUI : CL1661969;
Origin ID : C179331;
UMLS CUI : C5555618;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
