Preferred Label : Anti-4-1BB Fab/TriCD40L Fusion Protein IMB071703;
NCIt synonyms : XFab-a4-1BB/CD40L Bispecific Antibody IMB071703; XFab-a4-1BB/CD40L Fusion Protein IMB071703; 4-1BB Fab/TriCD40L Fusion Protein IMB071703;
NCIt definition : A bi-functional fusion protein consisting of a monovalent Fab fragment directed against
4-1BB (CD137; tumor necrosis factor receptor superfamily member 9; TNFRSF9) fused
to a CD40 ligand (CD40L; CD154; TRAP; TNFSF5) trimer, triCD40L, with potential immune
checkpoint inhibitory and antineoplastic activities. Upon administration, anti-4-1BB
Fab/triCD40L fusion protein IMB071703 selectively targets and binds to both 4-1BB
expressed on T-cells and natural killer (NK) cells, and CD40 expressed on antigen-presenting
cells (APCs), including dendritic cells (DC), B-cells, T-cells, and NKs. The trimeric
binding of CD40L to CD40 (tumor necrosis factor receptor superfamily member 5; TNFRSF5)
induces CD40 trimerization and crosslinking, activates CD40, increases CD40-mediated
signaling and specifically induces proliferation and activation of DCs. The CD40 crosslinking
leads to 4-1BB receptor clustering, and the Fab fragment binding to 4-1BB activates
4-1BB-mediated signaling, induces cytotoxic T-lymphocyte (CTL) proliferation, cytokine
production and promotes a CTL-mediated anti-tumor immune response as well as NK-mediated
tumor cell killing in the tumor microenvironment (TME). 4-1BB, a surface glycoprotein
of the tumor necrosis factor receptor superfamily, is an inducible costimulatory receptor
that plays a key role in T-cell proliferation, survival and cytolytic activity, and
T-cell memory formation. CD40, a costimulatory cell surface receptor that belongs
to the TNF receptor family, plays a key role in DC maturation, and activation of antigen-specific
T cells.;
Molecule name : IMB-071703; IMB 071703;
Origin ID : C211534;
concept_is_in_subset
- has_target
