Preferred Label : CD47 Antagonist AUR103 Calcium;
NCIt synonyms : AUR-103 Calcium; AUR 103 Calcium; AUR103 Calcium; CD47 Antagonist AUR103 Ca;
NCIt definition : The calcium salt form of AUR103, an orally bioavailable, small molecule antagonist
of the human cell surface antigen CD47, with potential phagocytosis-inducing, immunostimulating
and antineoplastic activities. Upon oral administration, CD47 antagonist AUR103 calcium
binds to CD47 expressed on tumor cells and prevents the interaction of CD47 with its
ligand SIRPa, a protein expressed on phagocytic cells. This prevents CD47/SIRPa-mediated
signaling and abrogates the CD47/SIRPa-mediated inhibition of phagocytosis. This induces
pro-phagocytic signaling mediated by the binding of the pro-phagocytic signal calreticulin
(CRT), which is specifically expressed on the surface of tumor cells, to low-density
lipoprotein (LDL) receptor-related protein (LRP), expressed on macrophages. This results
in macrophage activation and the specific phagocytosis of tumor cells. In addition,
blocking CD47 signaling activates both an anti-tumor cytotoxic T-lymphocyte (CTL)
immune response and T cell-mediated killing of CD47-expressing tumor cells. CD47,
also called integrin-associated protein (IAP), is a tumor-associated antigen (TAA)
expressed on normal, healthy hematopoietic stem cells (HSC) and overexpressed on the
surface of a variety of cancer cells. Expression of CD47, and its interaction with
SIRPa, leads to the inhibition of macrophage activation and protects cancer cells
from phagocytosis, which allows cancer cells to proliferate.;
NCI Metathesaurus CUI : CL1913086;
Origin ID : C193464;
UMLS CUI : C5785773;
Semantic type(s)
- concept_is_in_subset
- has_target
