Preferred Label : Anti-CD47 ADC SGN-CD47M;
NCIt synonyms : ADC SGN-CD47M; Anti-CD47 Antibody-drug Conjugate SGN-CD47M;
NCIt definition : An antibody-drug conjugate (ADC) consisting of a monoclonal antibody directed against
human cell surface antigen CD47 conjugated to an as of yet not fully elucidated toxin,
with potential antineoplastic activity. Upon administration of SGN-CD47M, the anti-CD47
monoclonal antibody moiety targets and binds to CD47 on tumor cell surfaces; upon
internalization, the toxin moiety kills tumor cells through a mechanism of action
that has not been elucidated. CD47, also called integrin-associated protein (IAP),
is a tumor-associated antigen (TAA) expressed on normal, healthy hematopoietic stem
cells (HSCs) and overexpressed on the surface of a variety of cancer cells.;
Molecule name : SGN-CD47M; SGN CD47M;
NCI Metathesaurus CUI : CL1407430;
Origin ID : C173421;
UMLS CUI : C5417975;
Semantic type(s)
- concept_is_in_subset
- has_target
