Preferred Label : Ligufalimab;
NCIt synonyms : Anti-CD47 Monoclonal Antibody AK117;
NCIt definition : A humanized immunoglobulin G4 (IgG4) monoclonal antibody targeting leukocyte surface
antigen CD47, with potential immune checkpoint inhibitory and antineoplastic activities.
Upon administration, ligufalimab targets and binds to CD47 expressed on tumor cells,
blocking the interaction of CD47 with signal regulatory protein alpha (SIRPa) expressed
on phagocytic cells. This prevents CD47/SIRPa-mediated signaling and abrogates the
CD47/SIRPa-mediated inhibition of macrophage activation and phagocytosis of cancer
cells. This induces pro-phagocytic signaling mediated by the binding of calreticulin
(CRT), which is specifically expressed on the surface of tumor cells, to low-density
lipoprotein (LDL) receptor-related protein-1 (LRP-1), which is expressed on macrophages,
and results in macrophage activation and the specific phagocytosis of tumor cells.
CD47, also called integrin-associated protein (IAP), is a tumor-associated antigen
(TAA) expressed on normal, healthy hematopoietic stem cells (HSCs) and overexpressed
on the surface of a variety of cancer cells. Expression of CD47, and its interaction
with SIRPa, leads to the inhibition of macrophage activation and protects cancer cells
from phagocytosis, thereby allowing cancer cells to proliferate.;
UNII : 1S4338NZB8;
CAS number : 2428381-55-7;
Molecule name : AK-117; AK 117;
NCI Metathesaurus CUI : CL1642925;
Origin ID : C176868;
UMLS CUI : C5667214;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
