Preferred Label : Anti-CD47 Monoclonal Antibody STI-6643;
NCIt related terms : STI-6643;
NCIt definition : A human monoclonal antibody targeting leukocyte surface antigen CD47, with potential
immune checkpoint inhibitory and antineoplastic activities. Upon administration, anti-CD47
monoclonal antibody STI-6643 targets and binds to CD47 expressed on tumor cells, blocking
the interaction of CD47 with signal regulatory protein alpha (SIRPa) expressed on
phagocytic cells. This prevents CD47/SIRPa-mediated signaling and abrogates the CD47/SIRPa-mediated
inhibition of macrophage activation and phagocytosis of cancer cells. This induces
pro-phagocytic signaling mediated by the binding of calreticulin (CRT), which is specifically
expressed on the surface of tumor cells, to low-density lipoprotein (LDL) receptor-related
protein-1 (LRP-1), which is expressed on macrophages, and results in macrophage activation
and the specific phagocytosis of tumor cells. CD47, also called integrin-associated
protein (IAP), is a tumor-associated antigen (TAA) expressed on normal, healthy hematopoietic
stem cells (HSCs) but is overexpressed on the surface of a variety of cancer cells
and contributes to poor prognosis. Expression of CD47, and its interaction with SIRPa,
leads to the inhibition of macrophage activation and protects cancer cells from phagocytosis,
thereby allowing cancer cells to proliferate. Compared to other anti-CD47 monoclonal
antibodies, STI-6643 shows decreased binding to red blood cells (RBCs). This may prevent
adverse effects such as anemia that can result from the blockade of CD47 expressed
on RBCs. In addition, STI-6643 has a minimal effect on T-, B- or natural killer (NK)
cell depletion which may further improve its efficacy by preserving infiltrating anti-tumor
immune cells.;
UNII : 68SNC9B4YR;
CAS number : 2376730-61-7; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 2376730-61-7
alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo
G-SRS /a ;
Molecule name : STI 6643; STI-6643;
NCI Metathesaurus CUI : CL1663465;
Origin ID : C180830;
UMLS CUI : C5556654;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
