Preferred Label : Anti-CD47 Monoclonal Antibody ZL-1201;
NCIt definition : A humanized immunoglobulin G4 (IgG4) monoclonal antibody targeting leukocyte surface
antigen CD47, with potential immune checkpoint inhibitory and antineoplastic activities.
Upon administration, anti-CD47 monoclonal antibody ZL-1201 targets and binds to CD47
expressed on tumor cells, blocking the interaction of CD47 with signal regulatory
protein alpha (SIRPa) expressed on phagocytic cells. This prevents CD47/SIRPa-mediated
signaling and abrogates the CD47/SIRPa-mediated inhibition of macrophage activation
and phagocytosis of cancer cells. This induces pro-phagocytic signaling mediated by
the binding of calreticulin (CRT), which is specifically expressed on the surface
of tumor cells, to low-density lipoprotein (LDL) receptor-related protein-1 (LRP-1),
which is expressed on macrophages, and results in macrophage activation and the specific
phagocytosis of tumor cells. CD47, also called integrin-associated protein (IAP),
is a tumor-associated antigen (TAA) expressed on normal, healthy hematopoietic stem
cells (HSCs) and overexpressed on the surface of a variety of cancer cells. Expression
of CD47, and its interaction with SIRPa, leads to the inhibition of macrophage activation
and protects cancer cells from phagocytosis, thereby allowing cancer cells to proliferate.;
Molecule name : ZL 1201; ZL-1201;
NCI Metathesaurus CUI : CL1412925;
Origin ID : C175603;
UMLS CUI : C5446654;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
