Integrin Alpha-9

Preferred Label : Integrin Alpha-9;

NCIt synonyms : ITGA9; Integrin Alpha-RLC; Integrin Subunit Alpha 9;

NCIt definition : Integrin alpha-9 (1035 aa, 114 kDa) is encoded by the human ITGA9 gene. This protein is involved in cell-matrix binding and cell adhesion-dependent signaling.;

NCIt note : Like integrin alpha-4 (ITGA4), ITGA9 is not cleaved and lacks an I domain.; A heterodimer consisting of integrins alpha-9 (ITGA9) and beta-1 (ITGB1) is the functional, cell membrane-bound receptor for vascular cell adhesion protein 1 (VCAM1), thrombospondin-1 (THBS1), cytotactin and osteopontin.;

Details

Origin ID

C150272;

UMLS CUI

C2717020;

Automatic exact mappings (from CISMeF team)
- Integrin, alpha-9 [OMIM gene]
- integrin alpha9 [MeSH Supplementary Concept]
- integrin alpha9 [MeSH concept]
- integrin subunit alpha 9 [HGNC gene]
OMIM relation
- Integrin, alpha-9 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- ITGA9 protein, human [MeSH concept]
- ITGA9 protein, human [MeSH Supplementary Concept]
gene_encodes_gene_product
- Cell Adhesion Molecule Gene [NCIt concept]
- ITGA9 Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_biomarker_type
- Cluster of Differentiation [NCIt concept]
gene_product_is_element_in_pathway
- Actin Cytoskeleton Regulation Pathway [NCIt concept]
- Arf6 Trafficking Pathway [NCIt concept]
- Arrhythmogenic Right Ventricular Cardiomyopathy Pathway [NCIt concept]
- Dilated Cardiomyopathy Pathway [NCIt concept]
- ECM-Receptor Interaction Signaling Pathway [NCIt concept]
- Focal Adhesion Pathway [NCIt concept]
gene_product_is_physical_part_of
- Integrin [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Adhesion Process [NCIt concept]
- Cell-Matrix Adhesion Process [NCIt concept]
- Heterodimerization [NCIt concept]
- Ligand Binding [NCIt concept]
- Receptor Signaling [NCIt concept]

Keyword's position in hierarchy(ies) :

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