Collagen Alpha-3(VI) Chain

Preferred Label : Collagen Alpha-3(VI) Chain;

NCIt synonyms : Type VI Collagen Alpha 3 Chain; Collagen VI, Alpha-3 Polypeptide; Collagen Type VI Alpha 3 Chain; COL6A3; Collagen Type VI Alpha 3 Polypeptide;

NCIt definition : Collagen alpha-3(VI) chain (3177 aa, 344 kDa) is encoded by the human COL6A3 gene. This protein plays a role in extracellular matrix formation and cell-matrix adhesion in connective tissues.;

NCIt note : Collagen alpha-3(VI) chain is much larger than the alpha-1 and -2 chains due to an increased number of von Willebrand Factor type A (vWFA) subdomains in the amino terminal globular domain of the alpha-3 chain. (EntrezGene); Monomeric triple-helical type VI collagen consists of three different alpha chains. These monomers are assembled intracellularly into dimers and tetramers bound by interchain disulfide linkages. Following processing and secretion, the tetramers bind end-to-end to form double-beaded collagen VI microfibrils. (Ann N Y Acad Sci. 1985;460:25-37.);

NCI Metathesaurus CUI : CL552369;

Details

Origin ID

C150667;

UMLS CUI

C4724726;

Automatic exact mappings (from CISMeF team)
- Collagen, type VI, alpha-3 [OMIM gene]
- collagen type VI alpha 3 chain [ORDO Gene]
- collagen type VI alpha 3 chain [HGNC gene]
- collagen type vi [MeSH Descriptor]
OMIM relation
- Collagen, type VI, alpha-3 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- COL6A3 Gene [NCIt concept]
- Collagen Gene [NCIt concept]
- Extracellular Matrix Protein Gene [NCIt concept]
- Structural Protein Gene [NCIt concept]
gene_product_expressed_in_tissue
- Connective Tissue [NCIt concept]
gene_product_has_associated_anatomy
- Extracellular Matrix [NCIt concept]
gene_product_is_element_in_pathway
- ECM-Receptor Interaction Signaling Pathway [NCIt concept]
- Focal Adhesion Pathway [NCIt concept]
- Integrin Angiogenesis Pathway [NCIt concept]
- Syndecan-1-Mediated Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Adhesion Process [NCIt concept]
- Cell Growth [NCIt concept]
- Cell Movement [NCIt concept]
- Cell-Matrix Adhesion Process [NCIt concept]
- Morphogenesis [NCIt concept]
- Organogenesis [NCIt concept]
- Wound Repair [NCIt concept]

Keyword's position in hierarchy(ies) :

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