Basement Membrane-Specific Heparan Sulfate Proteoglycan Core Protein

Preferred Label : Basement Membrane-Specific Heparan Sulfate Proteoglycan Core Protein;

NCIt synonyms : Perlecan; HSPG; PLC;

NCIt definition : Basement membrane-specific heparan sulfate proteoglycan core protein (4391 aa, 469 kDa) is encoded by the human HSPG2 gene. This protein is involved in both the mediation of cell adhesion and the structural integrity of the basement membrane.;

NCIt note : Proteolytic processing of basement membrane-specific heparan sulfate proteoglycan core protein produces the C-terminal peptide, endorepellin. This peptide can be further processed to produce the LG3 peptide. Both peptides inhibit angiogenesis. (UniProt);

Details

Origin ID

C95448;

UMLS CUI

C2987155;

Automatic exact mappings (from CISMeF team)
- Heparan sulfate proteoglycan [FMA entity]
- Heparan sulfate proteoglycan of basement membrane [OMIM gene]
- MHC class I peptide loading complex [GO term]
- Syndecan 2 [OMIM gene]
- Vital capacity [LOINC component]
- heparan sulfate proteoglycan 2 [ORDO Gene]
- heparan sulfate proteoglycans [MeSH Descriptor]
- heparan sulfate proteoglycans [MeSH concept]
- laryngeal cleft [MeSH Supplementary Concept]
- viral load [MeSH Descriptor]
- visual fields [MeSH Descriptor]
- vital capacity [MeSH Descriptor]
- vocal cords [MeSH Descriptor]
Currated CISMeF NLP mapping
- Perlecan [FMA entity]
- perlecan [MeSH concept]
- perlecan [MeSH Supplementary Concept]
OMIM relation
- Heparan sulfate proteoglycan of basement membrane [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
gene_encodes_gene_product
- Extracellular Matrix Protein Gene [NCIt concept]
- HSPG2 Gene [NCIt concept]
- Structural Protein Gene [NCIt concept]
gene_product_has_associated_anatomy
- Basement Membrane [NCIt concept]
- Extracellular Matrix [NCIt concept]
gene_product_has_chemical_classification
- Heparan Sulfate Proteoglycan [NCIt concept]
gene_product_has_structural_domain_or_motif
- EGF-Like Domain [NCIt concept]
- Immunoglobulin-Like C2-Type Domain [NCIt concept]
gene_product_is_element_in_pathway
- ECM-Receptor Interaction Signaling Pathway [NCIt concept]
gene_product_malfunction_associated_with_disease
- Schwartz-Jampel Syndrome [NCIt concept]
gene_product_plays_role_in_biological_process
- Angiogenic Process [NCIt concept]
- Cell Adhesion Process [NCIt concept]
- Cell Growth [NCIt concept]
- Cell Movement [NCIt concept]
- Morphogenesis [NCIt concept]
- Organogenesis [NCIt concept]
- Wound Repair [NCIt concept]

Keyword's position in hierarchy(ies) :

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