Heparan Sulfate Proteoglycan

Preferred Label : Heparan Sulfate Proteoglycan;

NCIt synonyms : HSPG;

NCIt definition : Heparan Sulfate Proteoglycan is an extracellular matrix and vascular basal lamina component. Heparan Sulfate is also an essential co-factor in cell-matrix adhesion processes, in cell-cell recognition systems, and in receptor-growth factor interactions. Degradation by heparanase is a key step in extravasation by tumor cells and migrating leukocytes, as well as in angiogenesis, wound healing, and smooth muscle proliferation. In basement membranes, heparan sulfate may stabilize other molecules and influence glomerular permeability and cell adhesion. (From OMIM 142461 and NCI);

ChEBI ID : CHEBI:24499; CHEBI:35721;

Details

Origin ID

C17300;

UMLS CUI

C0062503;

Currated CISMeF NLP mapping
- Heparan sulfate proteoglycan [FMA entity]
- heparan sulfate proteoglycans [MeSH Descriptor]
- heparan sulfate proteoglycans [MeSH concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Heparan sulfate proteoglycan [FMA entity]
- heparan sulfate proteoglycans [MeSH concept]
- heparan sulfate proteoglycans [MeSH Descriptor]
gene_product_has_associated_anatomy
- Extracellular Matrix [NCIt concept]
gene_product_has_chemical_classification
- Proteoglycan [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell-Matrix Adhesion Process [NCIt concept]
is_chemical_classification_of_gene_product
- Basement Membrane-Specific Heparan Sulfate Proteoglycan Core Protein [NCIt concept]
- Syndecan [NCIt concept]
- Syndecan-1 [NCIt concept]
- Syndecan-2 [NCIt concept]
is_target
- Belzupacap Sarotalocan [NCIt concept]

Keyword's position in hierarchy(ies) :

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