Preferred Label : Belzupacap Sarotalocan;
NCIt synonyms : VNC AU-011; Viral Nanoparticle Conjugates AU-011; HPV-NP AU-011; Human Papillomavirus Virus-like Particles Conjugated with IR700 Dye AU-011; Light-activated AU-011;
NCIt definition : A formulation composed of nanoparticles derived from the human papillomavirus (HPV-NPs)
and conjugated to the infrared (IR)-activated fluorescent dye IR700 (IR-700), with
potential antineoplastic activity. Upon intravitreal injection of belzupacap sarotalocan,
the HPV-NPs target and bind to heparan-sulfated proteoglycans (HSPG) expressed by
ocular melanoma cells. Upon irradiation with near-IR (NIR) light, the photosensitizer
IR700 becomes activated, generates reactive oxygen species (ROS) and selectively damages
the melanoma cell membrane, which induces necrosis of the melanoma cells while sparing
the surrounding, healthy non-HSPG-expressing tissue, and potentially preserving vision.
HSPGs are overexpressed on a variety of cancer cell types.;
UNII : DK0ZGA5Y2R;
CAS number : 2390462-37-8;
Molecule name : AU-011;
NCI Metathesaurus CUI : CL524973;
Origin ID : C137951;
UMLS CUI : C5671042;
Semantic type(s)
- concept_is_in_subset
- has_target
