Syndecan - CISMeF

Preferred Label : Syndecan;

NCIt synonyms : Syndecans;

NCIt definition : The syndecans are a family of cell-surface heparan sulphate proteoglycans that regulate cell behavior by binding extracellular matrix molecules such as growth factors. The syndecan family has four members, of which syndecan-1 is the most studied and best characterized. In squamous cell carcinoma of the head and neck low syndecan-1 expression has been associated with unfavorable overall survival and can be used as a prognostic factor.;

Details

Origin ID

C17335;

UMLS CUI

C0075691;

Automatic exact mappings (from CISMeF team)
- Syndecan 1 [OMIM gene]
- Syndecan-3 [MeSH Descriptor]
Currated CISMeF NLP mapping
- Syndecan [FMA entity]
- obsolete syndecan [GO term]
- syndecans [MeSH Descriptor]
- syndecans [MeSH concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Syndecan [FMA entity]
- syndecans [MeSH Descriptor]
- syndecans [MeSH concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_chemical_classification
- Heparan Sulfate Proteoglycan [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Adhesion Process [NCIt concept]
- Signal Transduction [NCIt concept]
- Wound Repair [NCIt concept]
is_chemical_classification_of_gene_product
- Syndecan-1 [NCIt concept]
- Syndecan-2 [NCIt concept]
- Syndecan-3 [NCIt concept]
- Syndecan-4 [NCIt concept]

Keyword's position in hierarchy(ies) :

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