NCIt definition : Human DNM2 wild-type allele is located in the vicinity of 19p13.2 and is approximately
118 kb in length. This allele, which encodes dynamin-2 protein, is involved in both
microtubule polymerization and GTPase activity. Mutation of the gene is associated
with centronuclear myopathy type 1 and Charcot-Marie-Tooth disease types dominant
intermediate B and 2M axonal.;
NCIt note : Somatic mutation of the DNM2 gene may be associated with early T-cell precursor acute
lymphoblastic leukemia. (Nature. 2012; 481:157-163.);