" /> BARD1 wt Allele - CISMeF





Preferred Label : BARD1 wt Allele;

NCIt synonyms : BRCA1 Associated RING Domain 1 wt Allele; BARD-1;

NCIt definition : Human BARD1 wild-type allele is located in the vicinity of 2q34-q35 and is approximately 1 kb in length. This allele, which encodes BRCA1-associated RING domain protein 1, plays a role in tumor suppression, apoptosis and cellular growth.;

NCIt note : The BARD-1 N-terminus heterodimerizes with BRCA1. BARD1/CSTF1 complex interacts with RNA Polymerase-2, which may inhibit pre-mRNA cleavage or polyadenylation. BARD-1 may be a part of the RNA Polymerase-2 holoenzyme that senses DNA damage; inhibition by CSTF1 may prevent erroneous polyadenylation at such sites. BARD-1 may mediate apoptosis and is processed during apoptosis. BARD-1 homodimer is more susceptible to proteolysis than BARD1/BRCA1. BARD-1 co-localizes in S phase with BRCA1 in subnuclear foci. BARD1/BRCA1 disrupted by tumorigenic Brca1-amino acid substitutions; BARD1/BRCA1 may be essential to BRCA1 tumor suppression. BARD1 defects occur in primary breast, ovarian, and uterine cancers.;

GenBank Accession Number : NM_000465;

Details


Keyword's position in hierarchy(ies) : arborescence

You can consult :


Nous contacter.
12/05/2024


[Home] [Top]

© Rouen University Hospital. Any partial or total use of this material must mention the source.