BARD1 Pathway - CISMeF

Preferred Label : BARD1 Pathway;

NCIt related terms : BRCA1-dependent Ub-ligase activity;

Alternative definition : BIOCARTA: BRCA1 is a breast and ovarian cancer tumor suppressor protein that associates with BARD1 to form a RING/RING heterodimer. The BRCA1/BARD1 RING complex functions as an ubiquitin (Ub) ligase with activity substantially greater than individual BRCA1 or BARD1 subunits. The BRCA1 tumor suppressor forms a heterodimer with the BARD1 protein, and the resulting complex functions as an E3 ubiquitin ligase that catalyzes the synthesis of polyubiquitin chains. UbcH5c and UbcH7 also interact with the BRCA1/BARD1 complex with similar affinity (not shown on this figure). Although the in vivo substrate(s) is not yet known, BRCA1 has been observed to undergo autoubiquitination and is capable of monoubiquitinating histones 2A and 2AX in vitro. (This definition may be outdated - see the DesignNote.);

NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/.;

Biocarta ID : h_bard1Pathway;

Details

Origin ID

C38999;

UMLS CUI

C1516117;

Semantic type(s)
- Molecular Function [UMLS semantic type]
has_gene_product_element
- BRCA1-Associated RING Domain Protein 1 [NCIt concept]
- Breast Cancer Type 1 Susceptibility Protein [NCIt concept]
- Fanconi Anemia Group A Protein [NCIt concept]
- Fanconi Anemia Group B Protein [NCIt concept]
- Fanconi Anemia Group C Protein [NCIt concept]
- Fanconi Anemia Group D2 Protein [NCIt concept]
- Fanconi Anemia Group E Protein [NCIt concept]
- Fanconi Anemia Group F Protein [NCIt concept]
- Fanconi Anemia Group G Protein [NCIt concept]
pathway_has_gene_element
- BARD1 wt Allele [NCIt concept]
- BRCA1 wt Allele [NCIt concept]
- FANCA wt Allele [NCIt concept]
- FANCC wt Allele [NCIt concept]
- FANCD2 wt Allele [NCIt concept]
- FANCE wt Allele [NCIt concept]
- FANCF wt Allele [NCIt concept]
- FANCG wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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