E3 Ubiquitin-Protein Ligase Makorin-1

Preferred Label : E3 Ubiquitin-Protein Ligase Makorin-1;

NCIt synonyms : Makorin Ring Finger Protein 1; EC 6.3.2.-, Formerly; Makorin 1; RING Finger Protein 61; Makorin-1; EC 2.3.2.27;

NCIt definition : E3 ubiquitin-protein ligase makorin-1 (482 aa, 53 kDa) is encoded by the human MKRN1 gene. This protein is involved in the ubiquitination of proteins that regulate both cell survival and gene expression.;

NCIt note : Substrates for E3 ubiquitin-protein ligase makorin-1 include FILIP1, p53/TP53, CDKN1A and TERT. (UniProt);

Details

Origin ID

C111936;

UMLS CUI

C3815872;

Automatic exact mappings (from CISMeF team)
- Makorin 1 [OMIM gene]
- makorin ring finger protein 1 [MeSH concept]
- makorin ring finger protein 1 [MeSH Supplementary Concept]
- makorin ring finger protein 1 [HGNC gene]
OMIM relation
- Makorin 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- MKRN1 Gene [NCIt concept]
- Transferase Gene [NCIt concept]
- Ubiquitin-Transferase Gene [NCIt concept]
gene_product_has_biochemical_function
- Ubiquitination Regulation Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- C3H1 Zinc Finger [NCIt concept]
- Ring Finger Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
gene_product_is_physical_part_of
- Ubiquitin Protein Ligase [NCIt concept]
gene_product_plays_role_in_biological_process
- Ubiquitinated Protein Degradation [NCIt concept]
- Ubiquitination [NCIt concept]

Keyword's position in hierarchy(ies) :

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