Preferred Label : C3H1 Zinc Finger;
NCIt synonyms : Zinc Finger C-X8-C-X5-C-X3-H Type;
NCIt definition : Zinc finger domains are thought to be involved in DNA-binding. Different types exist
depending on the cysteine residue positions. C-X8-C-X5-C-X3-H type zinc finger proteins
often function in cell cycle or growth regulation, e.g. human TIS11B (butyrate response
factor 1) and mouse TTP nuclear protein. The splicing factor U2AF 35-kD subunit, which
mediates protein-protein and protein-RNA interactions required for 3-prime splice
site selection, also contains this domain. Different CCCH zinc finger proteins interact
with the 3-prime UTR of various mRNA. This type of zinc finger is often present in
two copies. (NCI);
Origin ID : C14097;
UMLS CUI : C1511360;
Semantic type(s)
- is_structural_domain_or_motif_of_gene_product
