E2 Ubiquitin-Conjugating Enzyme

Preferred Label : E2 Ubiquitin-Conjugating Enzyme;

NCIt synonyms : Ubiquitin Carrier Enzyme; Ubiquitin-Conjugating Enzyme E2; Ubiquitin-Conjugating Enzyme; Ubiquitin Carrier Protein;

NCIt definition : An aminoacyltransferase that catalyzes the second step in the ubiquitination reaction via the transfer of activated ubiquitin from an E1 ubiquitin-activating enzyme to itself via transthioesterification.;

NCIt note : The IUBMB has recategorized E2 ubiquitin-conjugating enzymes as transferases (EC 2); specifically aminoacyltransferases (EC 2.3.2.-). There are 3 categories of E2 enzymes: E3-dependent (EC 2.3.2.23), E3-independent (EC 2.3.2.24) and N-terminal E2 Ubiquitin-Conjugating enzymes (EC 2.3.2.25) (2015);

Details

Origin ID

C133711;

UMLS CUI

C0084913;

Automatic exact mappings (from CISMeF team)
- Ubiquitin--protein ligase (substance) [SNOMED CT concept]
- Ubiquitin-Conjugating enzymes [MeSH concept]
- Ubiquitin-conjugating enzyme e2 a [OMIM gene]
- Ubiquitin-conjugating enzyme e2 s [OMIM gene]
- ubiquitin carrier proteins [MeSH Supplementary Concept]
- ubiquitin carrier proteins [MeSH concept]
- ubiquitin conjugating enzyme E2 S [HGNC gene]
- ubiquitin-conjugating enzymes [MeSH Descriptor]
Biochemical function of gene products
- UBE2E Family [NCIt concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- Ubiquitin-Conjugating enzymes [MeSH concept]
- ubiquitin-conjugating enzymes [MeSH Descriptor]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Transferase Gene [NCIt concept]
- Ubiquitin-Conjugating Enzyme Gene [NCIt concept]
gene_product_has_biochemical_function
- Ubiquitination Regulation Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Ubiquitinated Protein Degradation [NCIt concept]
- Ubiquitination [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients