" /> UBE2E Family - CISMeF





Preferred Label : UBE2E Family;

NCIt synonyms : Ubiquitin-Conjugating Enzyme E2 E Family; Ubiquitin-Conjugating Enzyme E2E Family;

NCIt definition : A family of E2 ubiquitin-conjugating enzymes (UBE2) that transfer ubiquitin from E1 ubiquitin-activating enzyme to the active site cysteine of the E2 enzyme. Then the ubiquitin is transferred from the E2 enzyme to the target protein by E3 ubiquitin ligases. The N-terminal extension found in UBE2E proteins may confer a strong preference for the monoubiquitination of substrates rather than polyubiquitination.;

NCIt note : There are at least 3 ubiquitin-conjugating enzyme E2 E family members E2 E1, E2 E2 and E2 E3.;

NCI Metathesaurus CUI : CL509677;

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Keyword's position in hierarchy(ies) : arborescence

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15/05/2024


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