TRIM24 wt Allele

Preferred Label : TRIM24 wt Allele;

NCIt synonyms : Transcriptional Intermediary Factor 1 Gene; Tripartite Motif-Containing 24 wt Allele; TIF1; hTIF1; TIF1ALPHA; PTC6; TIF1A; TF1A; RNF82;

NCIt definition : Human TRIM24 wild-type allele is located within 7q32-q34 and is approximately 130 kb in length. This allele, which encodes transcription intermediary factor 1-alpha protein, is involved in transcriptional regulation. Genetic mutation and a translocation t(7;10)(q32;q11) involving this gene and the human RET gene are associated with thyroid papillary carcinoma.;

NCIt note : The TRIM24 gene may be associated with breast cancer because it plays a role in the positive regulation of estrogen-dependent gene expression. (Nature. 2010; 468: 927-932.);

GenBank Accession Number : AF009353;

Details

Origin ID

C95282;

UMLS CUI

C0906566;

Currated CISMeF NLP mapping
- TIF1alpha [MeSH concept]
OMIM relation
- Tripartite motif-containing protein 24 [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
UMLS correspondences (same concept)
- TIF1alpha [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_associated_with_disease
- Thyroid Gland Papillary Carcinoma [NCIt concept]
gene_found_in_organism
- Human [NCIt concept]
gene_has_abnormality
- Chromosomal Translocation [NCIt concept]
gene_is_element_in_pathway
- Androgen Receptor Regulation Pathway [NCIt concept]
gene_plays_role_in_process
- Transcriptional Activation [NCIt concept]
- Transcriptional Regulation [NCIt concept]
- Ubiquitinated Protein Degradation [NCIt concept]
- Ubiquitination [NCIt concept]

Keyword's position in hierarchy(ies) :

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