E3 Ubiquitin-Protein Ligase TRIP12

Preferred Label : E3 Ubiquitin-Protein Ligase TRIP12;

NCIt synonyms : Thyroid Receptor-Interacting Protein 12; TRIP-12; EC 6.3.2.-, Formerly; TR-Interacting Protein 12; TRIP12; EC 2.3.2.26; Probable E3 Ubiquitin-Protein Ligase TRIP12;

NCIt definition : E3 ubiquitin-protein ligase TRIP12 (1992 aa, 220 kDa) is encoded by the human TRIP12 gene. This protein may be involved in proteasomal targeting.;

NCIt note : Probable E3 ubiquitin-protein ligase TRIP12 may modulate cell proliferation by targeting cyclin-dependent kinase inhibitor 2A, isoform 4 for degradation.;

Details

Origin ID

C91268;

UMLS CUI

C2604534;

OMIM relation
- Thyroid hormone receptor interactor 12 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- TRIP12 protein, human [MeSH concept]
- TRIP12 protein, human [MeSH Supplementary Concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- TRIP12 Gene [NCIt concept]
- Transferase Gene [NCIt concept]
- Ubiquitin-Transferase Gene [NCIt concept]
gene_product_has_associated_anatomy
- PA700 Regulatory Module [NCIt concept]
gene_product_has_biochemical_function
- Ubiquitination Regulation Protein [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Ubiquitin-mediated Proteolysis Pathway [NCIt concept]
gene_product_is_physical_part_of
- Ubiquitin Protein Ligase [NCIt concept]
gene_product_plays_role_in_biological_process
- Ubiquitinated Protein Degradation [NCIt concept]
- Ubiquitination [NCIt concept]

Keyword's position in hierarchy(ies) :

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