PA700 Regulatory Module

Preferred Label : PA700 Regulatory Module;

NCIt synonyms : PA700 Protein; PA700 Protein Complex; 19S Proteasome Regulatory Particle; 19S Regulatory Particle;

NCIt definition : Ubiquitinated proteins are degraded by a 26S ATP-dependent protease complex, composed of a 20S catalytic proteasome and two 19S PA700 regulatory modules. The multi-subunit PA700 complex binds two sites of the 20S proteasome and is composed of at least six related ATPases and approximately fifteen non-ATPase polypeptides. Each of the ATPases, PSMC1-6, contains an AAA (ATPases associated with diverse cellular activities) domain. A protein complex containing p42 and p50 enhances PA700 activation of the proteasome.;

Details

Origin ID

C13336;

UMLS CUI

C1518774;

Anatomic structure is physical part of
- 26S ATP-Dependent Proteasome [NCIt concept]
- Cell [NCIt concept]
Associated anatomy of gene products
- 26S Proteasome Complex Subunit SEM1 [NCIt concept]
- 26S Proteasome Non-ATPase Regulatory Subunit 11 [NCIt concept]
- 26S Proteasome Non-ATPase Regulatory Subunit 2 [NCIt concept]
- 26S Proteasome Non-ATPase Regulatory Subunit 3 [NCIt concept]
- E3 Ubiquitin-Protein Ligase TRIP12 [NCIt concept]
- Proteasomal Ubiquitin Receptor ADRM1 [NCIt concept]
Automatic exact mappings (from CISMeF team)
- proteasome regulatory particle [GO term]
Semantic type(s)
- Cell Component [UMLS semantic type]

Keyword's position in hierarchy(ies) :

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