26S Proteasome Complex Subunit SEM1

Preferred Label : 26S Proteasome Complex Subunit SEM1;

NCIt synonyms : Split Hand/Foot Malformation (Ectrodactyly) Type 1; Split Hand/Foot Malformation Type 1 Protein; Deleted in Split-Hand/Split-Foot Protein 1; Deleted in Split-Hand/Split-Foot 1 Region Protein; DSS1; Deleted in Split Hand/Split Foot Protein 1; DSS1 Protein; Split Hand/Foot Deleted Protein 1; Deleted in Split Hand-Split Foot Protein-1; 26S Proteasome Complex Subunit DSS1; SHFM1; SEM1;

NCIt definition : 26S proteasome complex subunit SEM1 (70 aa, 8 kDa) is encoded by the human SEM1 gene. This protein is involved in the modulation of proteasome activity.;

NCIt note : 26S proteasome complex subunit SEM can interact with the carboxyl terminal domain of Breast cancer type 2 susceptibility protein (BRCA2). This interaction stabilizes BRCA2. (UniProt);

Details

Origin ID

C25845;

UMLS CUI

C0665881;

OMIM relation
- Proteasome 26s subunit sem1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- SEM1 protein, human [MeSH Supplementary Concept]
- SEM1 protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Regulatory Gene [NCIt concept]
- SEM1 Gene [NCIt concept]
gene_product_expressed_in_tissue
- Skin [NCIt concept]
gene_product_has_associated_anatomy
- 26S ATP-Dependent Proteasome [NCIt concept]
- PA700 Regulatory Module [NCIt concept]
gene_product_has_chemical_classification
- Protein Complex Subunit [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- Acidic Region [NCIt concept]
gene_product_is_element_in_pathway
- Homologous Recombination Pathway [NCIt concept]
- Proteasome Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Cycle Process [NCIt concept]
- Limb Development [NCIt concept]
- Protein Degradation Process [NCIt concept]
- Protein-Protein Interaction [NCIt concept]

Keyword's position in hierarchy(ies) :

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