Homologous Recombination Pathway

Preferred Label : Homologous Recombination Pathway;

NCIt related terms : Homologous recombination;

Alternative definition : KEGG: Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.;

KEGG ID : hsa03440;

Details

Origin ID

C91483;

UMLS CUI

C2984295;

Automatic exact mappings (from CISMeF team)
- homologous recombination [MeSH Descriptor]
- homologous recombination [MeSH concept]
- homologous recombination [GO term]
- homologous recombination [COVID-19 Thesaurus concept]
Semantic type(s)
- Functional Concept [UMLS semantic type]
UMLS correspondences (same concept)
- homologous recombination [GO term]
has_gene_product_element
- 26S Proteasome Complex Subunit SEM1 [NCIt concept]
- BRCA1-A Complex Subunit Abraxas 1 [NCIt concept]
- BRISC and BRCA1-A Complex Member 2 [NCIt concept]
- Bloom Syndrome Protein [NCIt concept]
- Crossover Junction Endonuclease MUS81 [NCIt concept]
- DNA Polymerase Delta Catalytic Subunit [NCIt concept]
- DNA Polymerase Delta Subunit 3 [NCIt concept]
- DNA Polymerase Epsilon Catalytic Subunit A [NCIt concept]
- DNA Repair Protein RAD50 [NCIt concept]
- DNA Repair Protein RAD51 Homolog 1 [NCIt concept]
- DNA Repair Protein RAD51 Homolog 2 [NCIt concept]
- DNA Repair Protein RAD51 Homolog 3 [NCIt concept]
- DNA Repair Protein RAD51 Homolog 4 [NCIt concept]
- DNA Repair Protein RAD52 Homolog [NCIt concept]
- DNA Repair Protein XRCC2 [NCIt concept]
- DNA Repair Protein XRCC3 [NCIt concept]
- DNA Repair and Recombination Protein RAD54-Like [NCIt concept]
- DNA Repair and Recombination Protein RAD54B [NCIt concept]
- DNA Topoisomerase 3-Alpha [NCIt concept]
- DNA Topoisomerase 3-Beta-1 [NCIt concept]
- Double-Strand Break Repair Protein MRE11 [NCIt concept]
- Nibrin [NCIt concept]
- Replication Protein A 14 kDa [NCIt concept]
- Replication Protein A 32 kDa Subunit [NCIt concept]
- Replication Protein A 70 kDa DNA-Binding Subunit [NCIt concept]
- Single-Stranded DNA-Binding Protein, Mitochondrial [NCIt concept]
pathway_has_gene_element
- ABRAXAS1 wt Allele [NCIt concept]
- BABAM2 wt Allele [NCIt concept]
- BLM wt Allele [NCIt concept]
- MRE11 wt Allele [NCIt concept]
- MUS81 wt Allele [NCIt concept]
- POLD1 wt Allele [NCIt concept]
- POLD3 wt Allele [NCIt concept]
- POLE wt Allele [NCIt concept]
- RAD50 wt Allele [NCIt concept]
- RAD51 wt Allele [NCIt concept]
- RAD51B wt Allele [NCIt concept]
- RAD51C wt Allele [NCIt concept]
- RAD51D wt Allele [NCIt concept]
- RAD52 wt Allele [NCIt concept]
- RAD54B wt Allele [NCIt concept]
- RAD54L wt Allele [NCIt concept]
- RPA1 wt Allele [NCIt concept]
- RPA2 wt Allele [NCIt concept]
- RPA3 wt Allele [NCIt concept]
- SEM1 wt Allele [NCIt concept]
- SSBP1 wt Allele [NCIt concept]
- TOP3A wt Allele [NCIt concept]
- TOP3B wt Allele [NCIt concept]
- XRCC2 wt Allele [NCIt concept]
- XRCC3 wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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