NCIt synonyms : X-Ray Repair, Complementing Defective, in Chinese Hamster, 3 Gene; X-Ray Repair Cross-Complementing Protein 3 Gene; DNA Repair Protein XRCC3 Gene; X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 3 wt Allele; CMM6;
NCIt definition : Human XRCC3 wild-type allele is located in the vicinity of 14q32.3 and is approximately
18 kb in length. This allele, which encodes DNA-repair protein XRCC3, plays a role
in homologous recombination to maintain chromosomal stability and DNA damage repair.;
NCIt note : The XRCC3 gene at 14q32.3 encodes X-Ray Repair Cross Complementing Protein 3 (XRCC3),
a member of the RecA/Rad51-related protein family that participates in homologous
recombination to maintain chromosome stability and repair DNA damage. XRCC3 interacts
directly with RAD51 and may cooperate with RAD51 during recombinational repair. A
rare microsatellite polymorphism in this gene is associated with cancer in patients
of varying radiosensitivity and exposure to UV radiation is a major risk factor for
the development of malignant melanoma. DNA damage caused by UV radiation is thought
to play a major role in carcinogenesis. The association between polymorphisms in DNA
repair genes and the development of malignant melanoma, a T allele at position 18067
in exon 7 of the XRCC3 gene is significantly associated with melanoma development.;