Homologous Recombination

Preferred Label : Homologous Recombination;

NCIt definition : The process of exchange of genetic material between autonomous replicons, which depends on regions of extensive sequence homology between the participating DNA strands. This process involves double-strand breakage of one participant, resection of the break, and strand invasion, followed by formation, displacement and resolution of the Holliday junction. This process is involved in repairing broken DNA and creating combinations of genes that may be unique from the parent duplexes. Disruptions in this process can result in inviability, premature aging and predisposition to cancers and degenerative diseases.;

Details

Origin ID

C18144;

UMLS CUI

C0599773;

Automatic exact mappings (from CISMeF team)
- homologous recombination [GO term]
- homologous recombination [COVID-19 Thesaurus concept]
Currated CISMeF NLP mapping
- homologous recombination [MeSH Descriptor]
- homologous recombination [MeSH concept]
Semantic type(s)
- Genetic Function [UMLS semantic type]
UMLS correspondences (same concept)
- homologous recombination [MeSH concept]
- homologous recombination [MeSH Descriptor]
biological_process_involves_gene_product
- BCDX2 Complex [NCIt concept]
- Breast Cancer Type 2 Susceptibility Protein [NCIt concept]
- DNA Repair Protein RAD51 Homolog 2 [NCIt concept]
- DNA Repair Protein RAD52 Homolog [NCIt concept]
- DNA Repair Protein XRCC2 [NCIt concept]
- DNA Repair Protein XRCC3 [NCIt concept]
- DNA Repair and Recombination Protein RAD54-Like [NCIt concept]
- Flap Endonuclease GEN Homolog 1 [NCIt concept]
biological_process_is_part_of_process
- Metaphase Process [NCIt concept]
process_involves_gene
- BRCA1 Gene [NCIt concept]
- BRCA1 wt Allele [NCIt concept]
- BRCA2 Gene [NCIt concept]
- BRCA2 wt Allele [NCIt concept]
- DMC1 Gene [NCIt concept]
- DMC1 wt Allele [NCIt concept]
- GEN1 Gene [NCIt concept]
- GEN1 wt Allele [NCIt concept]
- Homologous Recombination Repair Gene [NCIt concept]
- MRE11 Gene [NCIt concept]
- MRE11 wt Allele [NCIt concept]
- MUS81 Gene [NCIt concept]
- MUS81 wt Allele [NCIt concept]
- NBN Gene [NCIt concept]
- NBN wt Allele [NCIt concept]
- RAD50 Gene [NCIt concept]
- RAD50 wt Allele [NCIt concept]
- RAD51 Family Gene [NCIt concept]
- RAD51 Gene [NCIt concept]
- RAD51 wt Allele [NCIt concept]
- RAD51B Gene [NCIt concept]
- RAD51B wt Allele [NCIt concept]
- RAD51C Gene [NCIt concept]
- RAD51C wt Allele [NCIt concept]
- RAD51D Gene [NCIt concept]
- RAD51D wt Allele [NCIt concept]
- RAD52 Gene [NCIt concept]
- RAD52 wt Allele [NCIt concept]
- RAD54B Gene [NCIt concept]
- RAD54B wt Allele [NCIt concept]
- RAD54L Gene [NCIt concept]
- RAD54L wt Allele [NCIt concept]
- RBBP8 Gene [NCIt concept]
- RBBP8 wt Allele [NCIt concept]
- XRCC2 Gene [NCIt concept]
- XRCC2 wt Allele [NCIt concept]
- XRCC3 Gene [NCIt concept]
- XRCC3 wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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