Preferred Label : Proteasome Pathway;
NCIt related terms : Proteasome;
Alternative definition : KEGG: The proteasome is a protein-destroying apparatus involved in many essential
cellular functions, such as regulation of cell cycle, cell differentiation, signal
transduction pathways, antigen processing for appropriate immune responses, stress
signaling, inflammatory responses, and apoptosis. It is capable of degrading a variety
of cellular proteins in a rapid and timely fashion and most substrate proteins are
modified by ubiquitin before their degradation by the proteasome. The proteasome is
a large protein complex consisting of a proteolytic core called the 20S particle and
ancillary factors that regulate its activity in various ways. The most common form
is the 26S proteasome containing one 20S core particle and two 19S regulatory particles
that enable the proteasome to degrade ubiquitinated proteins by an ATP-dependent mechanism.
Another form is the immunoproteasome containing two 11S regulatory particles, PA28
alpha and PA28 beta, which are induced by interferon gamma under the conditions of
intensified immune response. Other regulatory particles include PA28 gamma and PA200.
Although PA28 gamma also belongs to a family of activators of the 20S proteasome,
it is localized within the nucleus and forms a homoheptamer. PA28 gamma has been implicated
in the regulation of cell cycle progression and apoptosis. PA200 has been identified
as a large nuclear protein that stimulates proteasomal hydrolysis of peptides.;
KEGG ID : hsa03050;
Origin ID : C91521;
UMLS CUI : C1752727;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- has_gene_product_element
- pathway_has_gene_element
