proteasome endopeptidase complex

Preferred Label : proteasome endopeptidase complex;

MeSH definition : A large multisubunit complex that plays an important role in the degradation of most of the cytosolic and nuclear proteins in eukaryotic cells. It contains a 700-kDa catalytic sub-complex and two 700-kDa regulatory sub-complexes. The complex digests ubiquitinated proteins and protein activated via ornithine decarboxylase antizyme.;

MeSH synonym : complex, proteasome endopeptidase; macropain; multicatalytic endopeptidase complex; proteasome; proteinase, multicatalytic; endopeptidase complex, proteasome; macroxyproteinase; multicatalytic proteinase; prosome; 20s proteasome; proteasome, 20s; complex, multicatalytic endopeptidase; endopeptidase complex, multicatalytic;

MeSH hyponym : ingensin;

MeSH Related Number : ingensin; EC 3.4.25.1;

Registry Number MeSH : EC 3.4.25.1;

Related CAS MeSH : EC 3.4.25.1 (Ingensin);

Wikipedia link : https://en.wikipedia.org/wiki/Proteasome;

Is substance : O;

UNII : EC 3.4.25.1;

Details

Origin ID

D046988;

UMLS CUI

C0208355;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- analysis [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- 20S Proteasome [NCIt concept]
- Estazolam [NCIt concept]
- Multicatalytic endopeptidase complex (substance) [SNOMED CT concept]
- Proteasome [NCIt concept]
- Proteasome Pathway [NCIt concept]
- obsolete proteasome endopeptidase activity [GO term]
- proteasome complex [GO term]
- proteasome core complex [GO term]
- threonine-type endopeptidase activity [GO term]
Indexing information
- PSMC1 protein, human [MeSH Supplementary Concept]
- Psmc3 protein, rat [MeSH Supplementary Concept]
- RPN2a protein, arabidopsis [MeSH Supplementary Concept]
- Rpt2 protein, S cerevisiae [MeSH Supplementary Concept]
- Spg5 protein, S cerevisiae [MeSH Supplementary Concept]
Record concept(s)
- ingensin [MeSH concept]
- proteasome endopeptidase complex [MeSH concept]
Related MeSH Supplementary Concept(s)
- 26S proteasome non-ATPase regulatory subunit 13 [MeSH Supplementary Concept]
- AT1G13060 protein, Arabidopsis [MeSH Supplementary Concept]
- ATP dependent 26S protease [MeSH Supplementary Concept]
- Blm10 protein, S cerevisiae [MeSH Supplementary Concept]
- ECPAS protein, human [MeSH Supplementary Concept]
- Ecm29 protein, S cerevisiae [MeSH Supplementary Concept]
- Ecpas protein, mouse [MeSH Supplementary Concept]
- LMP7 protein [MeSH Supplementary Concept]
- NAS6 protein, S cerevisiae [MeSH Supplementary Concept]
- PA28 protein, rat [MeSH Supplementary Concept]
- PA700 proteasome activator [MeSH Supplementary Concept]
- PRE2 protein, S cerevisiae [MeSH Supplementary Concept]
- PRE3 protein, S cerevisiae [MeSH Supplementary Concept]
- PRE4 protein, S cerevisiae [MeSH Supplementary Concept]
- PSA2 protein, mouse [MeSH Supplementary Concept]
- PSMA1 protein, human [MeSH Supplementary Concept]
- PSMA2 protein, human [MeSH Supplementary Concept]
- PSMA3 protein, human [MeSH Supplementary Concept]
- PSMA4 protein, human [MeSH Supplementary Concept]
- PSMA5 protein, human [MeSH Supplementary Concept]
- PSMA6 protein, human [MeSH Supplementary Concept]
- PSMA6 protein, mouse [MeSH Supplementary Concept]
- PSMA6 protein, rat [MeSH Supplementary Concept]
- PSMA7 protein, human [MeSH Supplementary Concept]
- PSMB1 protein, human [MeSH Supplementary Concept]
- PSMB10 protein, human [MeSH Supplementary Concept]
- PSMB11 protein, human [MeSH Supplementary Concept]
- PSMB2 protein, human [MeSH Supplementary Concept]
- PSMB2 protein, mouse [MeSH Supplementary Concept]
- PSMB4 protein, human [MeSH Supplementary Concept]
- PSMB4 protein, rat [MeSH Supplementary Concept]
- PSMB5 protein, human [MeSH Supplementary Concept]
- PSMB6 protein, human [MeSH Supplementary Concept]
- PSMB6 protein, rat [MeSH Supplementary Concept]
- PSMB7 protein, human [MeSH Supplementary Concept]
- PSMC2 protein, human [MeSH Supplementary Concept]
- PSMC3 protein, human [MeSH Supplementary Concept]
- PSMC4 protein, human [MeSH Supplementary Concept]
- PSMC5 protein, human [MeSH Supplementary Concept]
- PSMC6 protein, human [MeSH Supplementary Concept]
- PSMD1 protein, human [MeSH Supplementary Concept]
- PSMD10 protein, danio rerio [MeSH Supplementary Concept]
- PSMD10 protein, human [MeSH Supplementary Concept]
- PSMD11 protein, human [MeSH Supplementary Concept]
- PSMD12 protein, human [MeSH Supplementary Concept]
- PSMD12 protein, mouse [MeSH Supplementary Concept]
- PSMD14 protein, human [MeSH Supplementary Concept]
- PSMD14 protein, mouse [MeSH Supplementary Concept]
- PSMD4 protein, human [MeSH Supplementary Concept]
- PSMD5 protein, human [MeSH Supplementary Concept]
- PSMD7 protein, human [MeSH Supplementary Concept]
- PSMD8 protein, human [MeSH Supplementary Concept]
- PSMD9 protein, human [MeSH Supplementary Concept]
- PSME1 protein, human [MeSH Supplementary Concept]
- PSME2 protein, human [MeSH Supplementary Concept]
- PSMF1 protein, human [MeSH Supplementary Concept]
- PUP2 protein, S cerevisiae [MeSH Supplementary Concept]
- Pre10 protein, S cerevisiae [MeSH Supplementary Concept]
- Pre6 protein, S cerevisiae [MeSH Supplementary Concept]
- Prosalpha4T1 protein, Drosophila [MeSH Supplementary Concept]
- Prosalpha4T2 protein, Drosophila [MeSH Supplementary Concept]
- Psma4 protein, mouse [MeSH Supplementary Concept]
- Psma8 protein, mouse [MeSH Supplementary Concept]
- Psmb10 protein, mouse [MeSH Supplementary Concept]
- Psmb11 protein, mouse [MeSH Supplementary Concept]
- Psmb5 protein, mouse [MeSH Supplementary Concept]
- Psmb5 protein, rat [MeSH Supplementary Concept]
- Psmc3 protein, mouse [MeSH Supplementary Concept]
- Psmc3 protein, rat [MeSH Supplementary Concept]
- Psmc5 protein, mouse [MeSH Supplementary Concept]
- Psmc5 protein, rat [MeSH Supplementary Concept]
- Psmd5 protein, mouse [MeSH Supplementary Concept]
- Psmd9 protein, mouse [MeSH Supplementary Concept]
- Psme1 protein, mouse [MeSH Supplementary Concept]
- Psme2 protein, mouse [MeSH Supplementary Concept]
- Psmf1 protein, mouse [MeSH Supplementary Concept]
- RPN-12 protein, C elegans [MeSH Supplementary Concept]
- RPN-6.1 protein, C elegans [MeSH Supplementary Concept]
- RPN1 protein, S cerevisiae [MeSH Supplementary Concept]
- RPN1 protein, human [MeSH Supplementary Concept]
- RPN10 protein, S cerevisiae [MeSH Supplementary Concept]
- RPN12 protein, S cerevisiae [MeSH Supplementary Concept]
- RPN13 protein, S cerevisiae [MeSH Supplementary Concept]
- RPN2 protein, S cerevisiae [MeSH Supplementary Concept]
- RPN2 protein, human [MeSH Supplementary Concept]
- RPN3 protein, S cerevisiae [MeSH Supplementary Concept]
- RPT-6 protein, C elegans [MeSH Supplementary Concept]
- RPT1 protein, S cerevisiae [MeSH Supplementary Concept]
- RPT4 protein, S cerevisiae [MeSH Supplementary Concept]
- RPT6 protein, S cerevisiae [MeSH Supplementary Concept]
- Rpn10 protein, rat [MeSH Supplementary Concept]
- Rpn14 protein, S cerevisiae [MeSH Supplementary Concept]
- Rpn5 protein, S cerevisiae [MeSH Supplementary Concept]
- Rpn7 protein, S cerevisiae [MeSH Supplementary Concept]
- Rpn8 protein, S cerevisiae [MeSH Supplementary Concept]
- Rpn9 protein, S cerevisiae [MeSH Supplementary Concept]
- Rpt3 protein, S pombe [MeSH Supplementary Concept]
- Rpt5 protein, Drosophila [MeSH Supplementary Concept]
- SCL1 protein, S cerevisiae [MeSH Supplementary Concept]
- SEM1 protein, S cerevisiae [MeSH Supplementary Concept]
- SEM1 protein, human [MeSH Supplementary Concept]
- ki antigen [MeSH Supplementary Concept]
- proteasome 26S subunit, non-ATPase 6, human [MeSH Supplementary Concept]
- proteasome activator PA700 subunit p58, human [MeSH Supplementary Concept]
- proteasome subunit beta5t, mouse [MeSH Supplementary Concept]
- psmc3 protein, zebrafish [MeSH Supplementary Concept]
Related MeSH term(s)
- proteasome inhibitors [MeSH Descriptor]
See also
- ubiquitin-protein ligase complexes [MeSH Descriptor]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- 20S Proteasome [NCIt concept]
- Multicatalytic endopeptidase complex (substance) [SNOMED CT concept]
- Proteasome [NCIt concept]

Keyword's position in hierarchy(ies) :

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